BACE-1

Cleavage of amyloid precursor protein (APP) into 40 or 42 amino acid amyloid β (aβ) peptides is a result of the action of two proteases β- and γ-secretase. The beta-site APP cleaving enzyme, or BACE-1, is a transmembrane aspartic protease that is localized in the Golgi and endosomes. Low levels of BACE-1 mRNA are found in most adult tissues with a higher level of expression in pancreas.

Product Specifications

Synonyms

BACE1; ASP2; BACE; HSPC104

NCBI Gene ID

23621

UniProt

P56817

Accession Number

NP_036236.1

Accession Number mRNA

NM_012104.4

Chromosomal Location

11q23.2-q23.3

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human recombinant BACE-1 (EC domain)

Clone

(#6J26)

Applications

WB, IHC (P)

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.