Amphiregulin
Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant human Amphiregulin is a 11.3 kDa glycoprotein consisting of 98 amino acid residues.
Product Specifications
Synonyms
AREG; AR; SDGF; AREGB; CRDGF
NCBI Gene ID
374
UniProt
P15514
Accession Number
NP_001648.1
Accession Number mRNA
NM_001657.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Amphiregulin
Clone
Rabbit IgG
Applications
WB, IF
Purification Method
Protein A purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Storage Conditions
Host or Source
Rabbit
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