AITRL
AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177 amino acids, including a 28 amino acid cytoplasmic region, a 21 amino acid transmembrane domain and a 128 amino acid extracellular domain. Recombinant human soluble AITRL is a 14.3 kDa protein, containing 126 amino acid residues corresponding to the extracellular domain of AITRL.
Product Specifications
Synonyms
TNFSF18; TL6; AITRL; GITRL; hGITRL
NCBI Gene ID
8995
UniProt
Q9UNG2
Accession Number
NP_005083.2
Accession Number mRNA
NM_005092.3
Chromosomal Location
1q23
Reactivity
Human
Cross Reactivity
Human
Sequence
ETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFI
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 97% by SDS-PAGE & HPLC analyses
Bioactivity
Length
126
Form
Lyophilized
Molecular Weight
14.3 kDa
Host or Source
E. coli
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