Aggrecan

Aggrecan, together with type II collagen, makes up to 90% of the dry weight of healthy cartilage. It hydrates the collagen network and thus provides cartilage with its properties of compressibility and elasticity. The N-terminal region of human Aggrecan (residues 20-675) consists of two globular domains (G1 and G2), flanking an interglobular domain (IGD) . The IGD contains the cleavage sites for matrix metalloproteinases and aggrecanases.

Product Specifications

Synonyms

ACAN; AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP

NCBI Gene ID

176

UniProt

E7ENV9

Accession Number

NP_001126.3

Accession Number mRNA

NM_001135.3

Chromosomal Location

15q26.1

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human Aggrecan

Clone

(#23A8)

Applications

WB, IHC (P)

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.