Aggrecan
Aggrecan, together with type II collagen, makes up to 90% of the dry weight of healthy cartilage. It hydrates the collagen network and thus provides cartilage with its properties of compressibility and elasticity. The N-terminal region of human Aggrecan (residues 20-675) consists of two globular domains (G1 and G2), flanking an interglobular domain (IGD) . The IGD contains the cleavage sites for matrix metalloproteinases and aggrecanases.
Product Specifications
Synonyms
ACAN; AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP
NCBI Gene ID
176
UniProt
E7ENV9
Accession Number
NP_001126.3
Accession Number mRNA
NM_001135.3
Chromosomal Location
15q26.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Aggrecan
Clone
(#23A8)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
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