ADAM-19
ADAM-19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrinβ) is a 95-100 kDa member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. After cleavage of a signal sequence and prodomain, the ectodomain circulates in plasma bound to α2 Macroglobulin. ADAM19 cleaves at sequences present in myelin basic protein, insulin β chain, TNFα, TRANCE and SCF. Over amino acids (aa) 205-705, mouse ADAM19 shares 87% aa sequence identity with human ADAM19.
Product Specifications
Synonyms
Adam19; M[b]; Mltnb; AL024287
NCBI Gene ID
11492
UniProt
O35674
Accession Number
NP_033746.1
Accession Number mRNA
NM_009616
Chromosomal Location
11 A5-B1.1; 11 20.0 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant protein of A Disintegrin and Metalloprotease-like Domain 19 ectodomain
Clone
(#11J23)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: 1:500-1000.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Rat
Isotype
IgG2
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