ADAM-17
The gene for the antigen encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
Product Specifications
Synonyms
ADAM17; CSVP; TACE; NISBD; ADAM18; CD156B
NCBI Gene ID
6868
UniProt
P78536
Accession Number
NP_003174
Accession Number mRNA
NM_003183
Chromosomal Location
2p25
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human ADAM-17, also called TACE
Clone
(#8C13)
Applications
WB, FC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: 1:500-1000, FC: 1:20-100
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG1
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