ACE-2
The protein encoded by the gene ACE belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
Product Specifications
Synonyms
ACE2; ACEH
NCBI Gene ID
59272
UniProt
Q9BYF1
Accession Number
NP_068576.1
Accession Number mRNA
NM_021804
Chromosomal Location
Xp22
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human ACE-2 recombinant protein (extracellular domain)
Clone
(#11A31)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
Frequently Asked Questions
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