Pebezertinib
Pebezertinib (BLU 451) is an orally active inhibitor for EGFR. Pebezertinib exhibits the ability to penetrate the central nervous system (CNS) . Pebezertinib can be used for research about non-small cell lung cancer carrying EGFR exon 20 insertion[1].
Product Specifications
CAS Number
[2769954-39-2]
Product Name Alternative
BLU 451; LNG-451
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pebezertinib.html
Concentration
10mM
Purity
99.56
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C(NC2=C(C3=CC=C(C(F)(F)F)C=C3)C=NC(NC4=CN(C)N=C4)=N2)=C1)F)C=C
Molecular Formula
C24H19F4N7O
Molecular Weight
497.45
References & Citations
[1]Zhou Y, et al., Anti-PD-1/L1 antibody plus anti-VEGF antibody vs. plus VEGFR-targeted TKI as first-line therapy for unresectable hepatocellular carcinoma: a network meta-analysis. Explor Target Antitumor Ther. 2024;5 (3) :568-580.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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