NIBR-LTSi

NIBR-LTSi is an orally active and selective LATS kinase inhibitor. NIBR-LTSi can activate YAP signaling. NIBR-LTSi promotes stem cell proliferation, maintains stemness and blocks differentiation. NIBR-LTSi accelerates liver regeneration following extended hepatectomy in mice[1].

Product Specifications

UNSPSC

12352005

Target

YAP

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/nibr-ltsi.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(NC2=CC=C(C=C2)O[C@H]3CNCCC3)=CC=NC4=C1C=CN4

Molecular Formula

C18H20N4O

Molecular Weight

308.38

References & Citations

[1]Namoto K, et al. NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo. Cell Stem Cell. 2024 Apr 4;31 (4) :554-569.e17.