Bemesetron
Product Specifications
UNSPSC Description
Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM[1]. Neuroprotective effect[2].
Target Antigen
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Bemesetron.html
Purity
99.0
Solubility
DMSO : 2 mg/mL (ultrasonic)
Smiles
O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C3=CC(Cl)=CC(Cl)=C3
Molecular Weight
314.21
References & Citations
[1]Peters JA, et al. An electrophysiological investigation of the properties of 5-HT<sub>3</sub> receptors of rabbit nodose ganglion neurones in culture. Br J Pharmacol. 1993 Oct;110(2):665-76.|[2]Lee HJ, et al. Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Life Sci. 2005 Dec 5;78(3):294-300.|[3]Silva SR, et al. Effects of 5-HT<sub>3</sub> receptor antagonists on neuroleptic-induced catalepsy in mice. Neuropharmacology. 1995 Jan;34(1):97-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B1541/Bemesetron-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1541/Bemesetron-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
40796-97-2
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
