KR-39038
Product Specifications
UNSPSC Description
KR-39038 is an orally active and potent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 0.02 μM. KR-39038 significantly inhibits angiotensin II-induced cellular hypertrophy through suppression of HDAC5 pathway in neonatal cardiomyocytes. KR-39038 shows profound anti-hypertrophic effects and improved cardiac function. KR-39038 can be used for heart failure research[1].
Target Antigen
G Protein-coupled Receptor Kinase (GRK); HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/kr-39038.html
Solubility
DMSO : 115 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
O=C1N=C(C2=C(Cl)C=CC=C2)NC3=CC(NCCCNCCCCNCCCN)=C(C=C13)F
Molecular Weight
475.00
References & Citations
[1]Lee JH, et al. KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure. Biomol Ther (Seoul). 2020 Sep 1;28(5):482-489.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143248/KR-39038-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143248/KR-39038-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2770300-35-9
Available Sizes
Curated Selection
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