TRPV1 antagonist 3
TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC50 of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant[1].
Product Specifications
CAS Number
[2765294-54-8]
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trpv1-antagonist-3.html
Purity
98.97
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C1=CC=CC(NC(N2CCC[C@H]2C3=NC=C(S3)C4=CC=CC=C4)=O)=C1)C
Molecular Formula
C23H25N3OS
Molecular Weight
391.53
References & Citations
[1]Yue Qiao, et al. Discovery of (S) -N- (3-isopropylphenyl) -2- (5-phenylthiazol-2-yl) pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist. Eur J Med Chem. 2022 Apr 5;233:114191.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPM8; TRPV1
Available Sizes
Curated Selection
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