TRPV1 antagonist 3

TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC50 of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant[1].

Product Specifications

CAS Number

[2765294-54-8]

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trpv1-antagonist-3.html

Purity

98.97

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(C1=CC=CC(NC(N2CCC[C@H]2C3=NC=C(S3)C4=CC=CC=C4)=O)=C1)C

Molecular Formula

C23H25N3OS

Molecular Weight

391.53

References & Citations

[1]Yue Qiao, et al. Discovery of (S) -N- (3-isopropylphenyl) -2- (5-phenylthiazol-2-yl) pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist. Eur J Med Chem. 2022 Apr 5;233:114191.