Gitoxin (Standard)
Gitoxin (Standard) is the analytical standard of Gitoxin. This product is intended for research and analytical applications. Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably[1].
Product Specifications
CAS Number
4562-36-1
UNSPSC
12352005
Target
Na+/K+ ATPase; Reference Standards
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gitoxin-standard.html
Smiles
O[C@@]([C@@]([C@@]1([H])C(CO2)=CC2=O)(CC3)C)(C[C@@H]1O)[C@@](CC[C@]4([H])C[C@H]5O[C@H](O[C@@H]6C)C[C@@H]([C@@H]6O[C@H](O[C@@H]7C)C[C@@H]([C@@H]7O[C@H](O[C@@H]8C)C[C@@H]([C@@H]8O)O)O)O)([H])[C@@]3([H])[C@]4(CC5)C
Molecular Formula
C41H64O14
Molecular Weight
780.94
References & Citations
[1]Danijela Krstić, et al. Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na+/K+-ATPase. J Enzyme Inhib Med Chem. 2004 Oct;19 (5) :409-15.|[2]Danijela Krstić, et al. Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na+/K+-ATPase. J Enzyme Inhib Med Chem. 2004 Oct;19 (5) :409-15.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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