Eflornithine
Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
Product Specifications
CAS Number
[70052-12-9]
Product Name Alternative
DFMO; MDL71782; RMI71782; α-difluoromethylornithine
UNSPSC
12352211
Hazard Statement
H302, H312, H332
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/eflornithine.html
Purity
99.87
Solubility
H2O : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC(CCCN)(C(F)F)C(O)=O
Molecular Formula
C6H12F2N2O2
Molecular Weight
182.17
Precautions
H302, H312, H332
References & Citations
[1]Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52.|[2]Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2 (3) :197-201; discussion 202.|[3]Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23 (5) :1495-501.|[4]Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19 (3) :297-312.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Trypanosoma
Citation 01
Adv Sci (Weinh) . 2025 Nov 21:e12508.|bioRxiv. 2024 Jan 15.|Cancer Nanotechnol. 2023 May 9.|Cell Rep. 2025 Feb 28;44 (3) :115370.|Clin Cancer Res. 2025 Nov 20.|Commun Biol. 2019 May 8:2:171.|Food Biosci. 2023 Oct, 55, 102970.|J Cardiovasc Transl Res. 2025 Jun;18 (3) :459-470.|JACC Basic Transl Sci. 2022 Aug 3;7 (8) :820-840.|Nat Commun. 2024 Mar 19;15 (1) :2461.|Oncotargets Ther. 2020 Nov 17;13:11697-11709.|Preprints. 2025 May 22.|RSC Adv. 2019 Apr 9;9 (20) :11026-11037.|The University of Texas at San Antonio. 2025.|Cell Rep. 2025 Jan 28;44 (1) :115123.|Front Oncol. 2021 Mar 11:11:636373.|Immunity. 2025 Aug 12;58 (8) :2019-2034.e11.|Phytomedicine. 2025 Jun:141:156660.|Sci Adv. 2023 May 19;9 (20) :eade0718.
Available Sizes
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