Homo-PROTAC cereblon degrader 1
Homo-PROTAC cereblon degrader 1 (compound 15a) is a highly potent and efficient Cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3[1].
Product Specifications
CAS Number
[2244520-98-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Homo-PROTAC_cereblon_degrader_1.html
Purity
99.66
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(N1C2CCC(NC2=O)=O)C3=CC=CC(NCCOCCOCCNC4=C5C(C(N(C6CCC(NC6=O)=O)C5=O)=O)=CC=C4)=C3C1=O
Molecular Formula
C32H32N6O10
Molecular Weight
660.63
Precautions
H302, H315, H319, H335
References & Citations
[1]Steinebach C, et al. Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS Chem Biol. 2018 Sep 21;13 (9) :2771-2782.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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