D-Fructose-6-phosphate (disodium)

D-Fructose 6-phosphate disodium is an endogenous metabolite. D-Fructose 6-phosphate disodium can be obtained by hydrolysis of Fructose-1,6-bisphosphatase (FBPase) . D-Fructose-6-phosphate disodium is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose-6-phosphate disodium can be used to detect glucosamine-6-phosphate synthase and TAL activities. D-Fructose 6-phosphate can be used to study Lewy body dementia.

Product Specifications

CAS Number

[26177-86-6]

Product Name Alternative

Tetrahydrofluoroene 60

UNSPSC

12352211

Hazard Statement

H370

Target

Endogenous Metabolite; FBPase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-fructose-6-phosphate-disodium.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : < 1 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OCC([C@H]([C@@H]([C@@H](COP(O[Na])(O[Na])=O)O)O)O)=O

Molecular Formula

C6H11Na2O9P

Molecular Weight

304.10

Precautions

H370

References & Citations

[1]Lee JH, et al. Crystal structure of rabbit phosphoglucose isomerase complexed with its substrate D-fructose 6-phosphate. Biochemistry. 2001 Jul 3;40 (26) :7799-805.|[2]Hardie DG, et al. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. 2012 Mar 22;13 (4) :251-62.|[3]Puskas F, et al. Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C. FASEB J. 2000 Jul;14 (10) :1352-61.|[4]Hiramatsu M, et al. Suppression by thyroid hormones of glucosamine-6-phosphate synthetase activity in rat sublingual glands. Arch Oral Biol. 1984;29 (10) :849-51.