SEH inhibitor-1
SEH inhibitor-1 (compound TCPU) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively[1].
Product Specifications
CAS Number
1208549-68-1
UNSPSC
12352005
Target
Epoxide Hydrolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/seh-inhibitor-1.html
Purity
99.62
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C=C1)OC(F)(F)F)NC2CCN(CC2)C(C3CC3)=O
Molecular Formula
C17H20F3N3O3
Molecular Weight
371.35
References & Citations
[1]Liu JY, et al. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. Eur J Pharm Sci. 2013;48 (4-5) :619-627.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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