Khellin
Product Specifications
UNSPSC Description
Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].
Target Antigen
EGFR
Type
Natural Products
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/khellin.html
Purity
99.89
Solubility
DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1C=C(C)OC2=C(OC)C(OC=C3)=C3C(OC)=C12
Molecular Weight
260.24
References & Citations
[1]Abdel-Sattar S Hamad Elgazwy, et al. Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors. J Enzyme Inhib Med Chem. 2013 Dec;28(6):1171-81.|[2]A Ubeda, et al. Relaxant actions of khellin on vascular smooth muscle. J Pharm Pharmacol . 1989 Apr;41(4):236-41.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B1394/Khellin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1394/Khellin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
82-02-0
Available Sizes
Curated Selection
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