Khellin

Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].

Product Specifications

CAS Number

[82-02-0]

UNSPSC

12352005

Hazard Statement

H301+H311+H331, H315, H319, H335

Target

EGFR

Type

Natural Products

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/khellin.html

Purity

99.66

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=C(C)OC2=C(OC)C(OC=C3)=C3C(OC)=C12

Molecular Formula

C14H12O5

Molecular Weight

260.24

Precautions

H301+H311+H331, H315, H319, H335

References & Citations

[1]Abdel-Sattar S Hamad Elgazwy, et al. Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors. J Enzyme Inhib Med Chem. 2013 Dec;28 (6) :1171-81.|[2]A Ubeda, et al. Relaxant actions of khellin on vascular smooth muscle. J Pharm Pharmacol . 1989 Apr;41 (4) :236-41.