Suc-Leu-Leu-Val-Tyr-AMC
Suc-Leu-Leu-Val-Tyr-AMC is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) [1].
Product Specifications
CAS Number
94367-21-2
Product Name Alternative
Suc-LLVY-AMC
UNSPSC
12171500
Hazard Statement
H302, H315, H319, H335
Target
Fluorescent Dye; Proteasome
Type
Dye Reagents
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Suc-Leu-Leu-Val-Tyr-AMC.html
Purity
99.66
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C1=CC=C(NC([C@@H](NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CCC(O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)C=C1O3)=CC3=O
Molecular Formula
C40H53N5O10
Molecular Weight
763.88
Precautions
H302, H315, H319, H335
References & Citations
[1]Roberta L. Debiasi, et al. Reovirus-Induced Apoptosis Is Preceded by Increased Cellular Calpain Activity and Is Blocked by Calpain Inhibitors. J Virol. 1999 Jan; 73 (1) : 695-701.|[2]Tadlock L, et al. Transforming growth factor-beta inhibition of proteasomal activity: a potential mechanism of growth arrest. Am J Physiol Cell Physiol. 2003 Aug;285 (2) :C277-85. Epub 2003 Mar 19.|[3]Gardner RC, et al. Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells. Biochem J. 2000 Mar, 2:447-54.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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