Suc-Leu-Leu-Val-Tyr-AMC

Suc-Leu-Leu-Val-Tyr-AMC is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) [1].

Product Specifications

CAS Number

[94367-21-2]

Product Name Alternative

Suc-LLVY-AMC

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Fluorescent Dye; Proteasome

Type

Dye Reagents

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Suc-Leu-Leu-Val-Tyr-AMC.html

Purity

99.66

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C1=CC=C(NC([C@@H](NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CCC(O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)C=C1O3)=CC3=O

Molecular Formula

C40H53N5O10

Molecular Weight

763.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Roberta L. Debiasi, et al. Reovirus-Induced Apoptosis Is Preceded by Increased Cellular Calpain Activity and Is Blocked by Calpain Inhibitors. J Virol. 1999 Jan; 73 (1) : 695-701.|[2]Tadlock L, et al. Transforming growth factor-beta inhibition of proteasomal activity: a potential mechanism of growth arrest. Am J Physiol Cell Physiol. 2003 Aug;285 (2) :C277-85. Epub 2003 Mar 19.|[3]Gardner RC, et al. Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells. Biochem J. 2000 Mar, 2:447-54.