Isoxsuprine
Isoxsuprine is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.
Product Specifications
CAS Number
395-28-8
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Adrenergic Receptor; iGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/isoxsuprine.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C(C(C)NC(COC2=CC=CC=C2)C)O)C=C1
Molecular Formula
C18H23NO3
Molecular Weight
301.38
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Falkay G, et al. Affinity of tocolytic agents on human placental and myometrial beta-adrenergic receptors. J Perinat Med. 1986;14 (2) :109-13.|[2]Kretschy N, et al. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer. 2013 Feb 19;108 (3) :570-8.|[3]Hill JW, et al. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One. 2014 May 7;9 (5) :e96761.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
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