MYF-03-69
MYF-03-69 (TEAD-IN-3) is a covalent and irreversible TEAD inhibitor with IC50s of 385, 143, 558 and 173 nM for TEAD1, TEAD2, TEAD3 and TEAD4. MYF-03-69 disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50 = 56 nM) and up-regulates apoptosis gene BMF. MYF-03-69 selectively inhibits mesothelioma cancer cells with defective Hippo signaling. MYF-03-69 can be used for the study of malignant pleural mesothelioma (MPM) [1].
Product Specifications
CAS Number
[2416418-11-4]
Product Name Alternative
TEAD-IN-3
UNSPSC
12352005
Target
Apoptosis; YAP
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tead-in-3.html
Purity
98.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)C(C=C1)=CC=C1CO[C@H]2[C@@](N3C=C(C4=CN=CC=C4)N=N3)([H])CN(C2)C(C=C)=O
Molecular Formula
C22H20F3N5O2
Molecular Weight
443.42
References & Citations
[1]Mengyang Fan, et al. Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling. Elife. 2022 Oct 27:11:e78810.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TEAD
Available Sizes
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