Buparvaquone

Buparvaquone is a hydroxynaphthoquinone antiprotozoal agent related to parvaquone and atovaquone.

Product Specifications

CAS Number

[88426-33-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Buparvaquone.html

Purity

99.64

Solubility

DMF : 25 mg/mL (ultrasonic) |DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 2 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C1C(CC2CCC(C(C)(C)C)CC2)=C(O)C(C3=C1C=CC=C3)=O

Molecular Formula

C21H26O3

Molecular Weight

326.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Müller J, et al. Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. Int J Parasitol Drugs Drug Resist. 2015 Feb 13;5 (1) :16-25.|[2]Reimão JQ, et al. Effectiveness of liposomal buparvaquone in an experimental hamster model of Leishmania (L.) infantum chagasi. Exp Parasitol. 2012 Mar;130 (3) :195-9.|[3]Garnier T, et al. In vivo studies on the antileishmanial activity of buparvaquone and its prodrugs. J Antimicrob Chemother. 2007 Oct;60 (4) :802-10.