CATL1 (heavy chain, Cleaved-Ala114) rabbit pAb

Catalytic activity: Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity. function: Important for the overall degradation of proteins in lysosomes. similarity: Belongs to the peptidase C1 family. subunit: Dimer of a heavy and a light chain linked by disulfide bonds.

Product Specifications

Background

Catalytic activity:Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity., function:Important for the overall degradation of proteins in lysosomes., similarity:Belongs to the peptidase C1 family., subunit:Dimer of a heavy and a light chain linked by disulfide bonds.

UniProt

P07711

Swiss Prot

P07711

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human CATL1 (heavy chain, Cleaved-Ala114)

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight

25 37kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

25 37kD

Fragment

IgG

Subcellular Location

Lysosome . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted, extracellular space . Secreted . Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. .; [Isoform 2]: Nucleus . Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and do not transit through the endoplasmic reticulum to localize to the nucleus (PubMed:15099520) . Nuclear location varies during the cell cycle, with higher levels during S phase (PubMed:15099520) . .