PfDHODH-IN-1
Product Specifications
UNSPSC Description
PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity[1][2].
Target Antigen
DNA/RNA Synthesis; Lactate Dehydrogenase; Parasite
Type
Reference compound
Related Pathways
Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pfdhodh-in-1.html
Smiles
O=C(NC1=CC=C(C(F)(F)F)C=C1)/C(C#N)=C(C2CC2)\O
Molecular Weight
296.24
References & Citations
[1]Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93.|[2]Hou X, et al. QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. SAR QSAR Environ Res. 2016;27(2):101-24.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-135648/PfDHODH-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-135648/PfDHODH-IN-1-SDS-MedChemExpress.pdf
CAS Number
183945-55-3
Available Sizes
Curated Selection
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