5-NIdR
5-NIdR (1- (β-D-2-Deoxyribofuranosyl) -5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide. 5-NIdR induces cancer cells apoptosis and arrests cell cycle at G0 phase. 5-NIdR enhances Temozolomide anti-tumor efficacy in murine glioblastoma model[1].
Product Specifications
CAS Number
191421-10-0
Product Name Alternative
1- (β-D-2-Deoxyribofuranosyl) -5-nitroindole
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-nidr.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=[N+](C1=CC(C=CN2[C@@H]3O[C@H](CO)[C@@H](O)C3)=C2C=C1)[O-]
Molecular Formula
C13H14N2O5
Molecular Weight
278.26
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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