NIH-12848
NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.
Product Specifications
CAS Number
[959551-10-1]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
PI5P4K
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/NIH-12848.html
Purity
99.96
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC(C1=CC=CC=C1C2=NC(NCC3=CC=CS3)=C4C=CC=CC4=N2)(F)F
Molecular Formula
C20H14F3N3S
Molecular Weight
385.41
Precautions
H315, H319, H335
References & Citations
[1]Clarke JH, et al. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Biochem J. 2015 Mar 1;466 (2) :359-67.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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