Diallyl disulfide

Diallyl disulfide, an active compound in garlic oil, is an orally active human squalene monooxygenase inhibitor with an IC50 of 400 μM for squalene epoxidation. Diallyl disulfide exhibits obvious anti-inflammatory, anti-oxidative, antidepressant and anti-tumor activities[1][2][3][4].

Product Specifications

CAS Number

[2179-57-9]

UNSPSC

12352100

Hazard Statement

H227, H301, H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/diallyl-disulfide.html

Purity

99.8

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C=CCSSCC=C

Molecular Formula

C6H10S2

Molecular Weight

146.27

Precautions

H227, H301, H315, H319, H335

References & Citations

[1]Gupta N, et al. Garlic and garlic-derived compounds inhibit human squalene monooxygenase. J Nutr. 2001;131 (6) :1662-1667. |[2]You-Sheng Huang, et al. Diallyl disulfide inhibits the proliferation of HT-29 human colon cancer cells by inducing differentially expressed genes. Mol Med Rep. 2011 May-Jun;4 (3) :553-9.|[3]Xiaoyou Wei, et al. Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress. Inflammation. 2021 Aug;44 (4) :1381-1395.|[4]Aline de Oliveira Pontes Cardoso, et al. Diallyl disulfide prevents cigarette smoke-induced emphysema in mice. Pulm Pharmacol Ther. 2021 Aug:69:102053.