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SHP2 protein degrader-1

Product Specifications

UNSPSC Description

SHP2 protein degrader-1 is a potent allosteric inhibitor of SHP2. SHP2 protein degrader-1 induces SHP2 degradation and cell apoptosis. SHP2 protein degrader-1 has the potential for researching SHP2 related diseases[1].

Target Antigen

Apoptosis; Phosphatase; PROTACs; SHP2

Type

Reference compound

Related Pathways

Apoptosis;Metabolic Enzyme/Protease;PROTAC;Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp2-protein-degrader-1.html

Solubility

DMSO : 110 mg/mL (ultrasonic)

Smiles

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCOCCOCCN4N=NC(CNC5(CCN(CC5)C6=CN=C(C7=C(Cl)C(Cl)=CC=C7)C(N)=N6)C)=C4)=CC=C3)=O)=O

Molecular Weight

908.83

References & Citations

[1]Zheng M, et al. Novel PROTACs for degradation of SHP2 protein. Bioorg Chem. 2021;110:104788.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-145159/SHP2-protein-degrader-1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-145159/SHP2-protein-degrader-1-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2624181-69-5

Available Sizes

Curated Selection

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