SHP2 protein degrader-1
SHP2 protein degrader-1 is a potent allosteric inhibitor of SHP2. SHP2 protein degrader-1 induces SHP2 degradation and cell apoptosis. SHP2 protein degrader-1 has the potential for researching SHP2 related diseases[1].
Product Specifications
CAS Number
[2624181-69-5]
UNSPSC
12352005
Target
Apoptosis; Phosphatase; PROTACs; SHP2
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp2-protein-degrader-1.html
Purity
98.94
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCOCCOCCN4N=NC(CNC5(CCN(CC5)C6=CN=C(C7=C(Cl)C(Cl)=CC=C7)C(N)=N6)C)=C4)=CC=C3)=O)=O
Molecular Formula
C42H51Cl2N11O8
Molecular Weight
908.83
References & Citations
[1]Zheng M, et al. Novel PROTACs for degradation of SHP2 protein. Bioorg Chem. 2021;110:104788.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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