MI-3
Product Specifications
UNSPSC Description
MI-3 (Menin-MLL inhibitor 3) is a potent and high affinity menin-MLL inhibitor with an IC50 of 648 nM and a Kd of 201 nM[1].
Target Antigen
Apoptosis; Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MI-3.html
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
CC(C)C1=CC2=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C2S1
Molecular Weight
375.55
References & Citations
[1]Grembecka J, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nature Chemical Biology (2012), 8(3), 277-284.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15223/MI-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15223/MI-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1271738-59-0
Available Sizes
Curated Selection
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