IL-12 beta, Rabbit (HEK293, His)

IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer[1]. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT[3]. IL-12 beta Protein consists of 335 amino acids (M1-N324) with a fibronectin type-III domain (233-324 a.a). IL-12 beta Protein, Rabbit is produced in HEK293 cells with a C-Terminal His-tag.

IWELEKDVYV VELDWYPDAP GETVVLTCDT SEEDGITWTS EQSNKVLGSG KTLTILVKEF GDAGQYTCHK GDKVLGHSKV LLHKKEDGIW STDILKDQKE PKSKTFLKCE AKNYSGHFTC WWLTAISRDV KFSVKSNRGS SDPQGVTCGV PERVSVNHTE YKYSVECQED NACPAAEESL HLEVMLDAIH KLKYENYTSS FFIRDIIKPD PPQNLQMKPL KNSRHVEVSW EYPDTWSTPH SYFSLTFCVQ VQNKNKKEKK DRLCVDKTSA TVMCHKDAKI RVQARDRYYS SSWSEWAFVS CN

[1]Lu X. Impact of IL-12 in Cancer. Curr Cancer Drug Targets. 2017;17(8):682-697.|[2]Gunsten S, et al. IL-12 p80-dependent macrophage recruitment primes the host for increased survival following a lethal respiratory viral infection. Immunology. 2009 Apr;126(4):500-13.|[3]Gotthardt D, Trifinopoulos J, Sexl V, Putz EM. JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation. Front Immunol. 2019 Nov 12;10:2590.|[4]Tait Wojno ED, Hunter CA, Stumhofer JS. The Immunobiology of the Interleukin-12 Family: Room for Discovery. Immunity. 2019 Apr 16;50(4):851-870.|[5]Subbian S, et al. Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis. Cell Commun Signal. 2013 Feb 28;11(1):16.