BF 227
Product Specifications
UNSPSC Description
BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.
Target Antigen
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BF_227.html
Purity
98.88
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CN(C)C1=NC=C(S1)/C=C/C2=NC3=CC=C(OCCF)C=C3O2
Molecular Weight
333.38
References & Citations
[1]Kudo Y, et al. Development of amyloid imaging PET probes for an early diagnosis of Alzheimer's disease. Minim Invasive Ther Allied Technol. 2006;15(4):209-13.|[2]Furukawa K, et al. Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET. J Neurol. 2010 May;257(5):721-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-105252A/BF-227-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-105252A/BF-227-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
845647-80-5
Available Sizes
Curated Selection
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