BF 227

BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.

Product Specifications

CAS Number

[845647-80-5]

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/BF_227.html

Purity

98.88

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CN(C)C1=NC=C(S1)/C=C/C2=NC3=CC=C(OCCF)C=C3O2

Molecular Formula

C16H16FN3O2S

Molecular Weight

333.38

References & Citations

[1]Kudo Y, et al. Development of amyloid imaging PET probes for an early diagnosis of Alzheimer's disease. Minim Invasive Ther Allied Technol. 2006;15 (4) :209-13.|[2]Furukawa K, et al. Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET. J Neurol. 2010 May;257 (5) :721-7.