JB-95

JB-95, a β-hairpin macrocyclic peptide, exhibits potent antimicrobial activity against Escherichia coli. JB-95 can selectively disrupt the outer membrane but not the inner membrane of E. coli[1].

Product Specifications

CAS Number

[1873323-60-4]

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/jb-95.html

Purity

99.52

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@](C(N[C@@H](C(N[C@H](C(N[C@H]1CCCCN)=O)CC2=CNC3=CC=CC=C23)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)[C@@H](NC([C@@](CCC4)([H])N4C([C@](CCC5)([H])N5C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CCCNC(N)=N)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)=O)CC6=CNC7=CC=CC=C67

Molecular Formula

C92H151N35O14

Molecular Weight

1971.41

References & Citations

[1]Urfer M, et, al. A Peptidomimetic Antibiotic Targets Outer Membrane Proteins and Disrupts Selectively the Outer Membrane in Escherichia coli. J Biol Chem. 2016 Jan 22;291 (4) :1921-1932.