(2R,3R) -Firazorexton

(2R,3R) -Firazorexton ((2R,3R) -TAK-994 free base) is an isomer of Firazorexton (HY-137440) . Firazorexton is an orally active, brain-penetrating orexin type 2 receptor (OX2R) agonist that may improve narcolepsy-like symptoms[1]..

Product Specifications

CAS Number

[2692692-00-3]

Product Name Alternative

(2R,3R) -TAK-994 (free base)

UNSPSC

12352005

Target

Orexin Receptor (OX Receptor)

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2r-3r-firazorexton.html

Purity

99.85

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CC(C)(O)C(N(CC[C@H]1NS(C)(=O)=O)[C@@H]1CC2=C(C(C3=CC(F)=CC(F)=C3)=CC=C2)F)=O

Molecular Formula

C22H25F3N2O4S

Molecular Weight

470.51

References & Citations

[1]Ishikawa T, Hara H, Kawano A, Tohyama K, Kajita Y, Miyanohana Y, Koike T, Kimura H. TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy. J Pharmacol Exp Ther. 2023 Jun;385 (3) :193-204.