GNE-0946
GNE-0946 is a potent and selective RORγ (RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.
Product Specifications
CAS Number
[1677667-24-1]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/GNE-0946.html
Concentration
10mM
Purity
98.11
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC(C2=C3N(C(C(C4=C(C(F)(F)F)C=CC=C4Cl)=O)=N2)C=CC=C3)=CC=C1C(O)=O
Molecular Formula
C22H12ClF3N2O4
Molecular Weight
460.79
References & Citations
[1]Fauber BP, et al. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett. 2015 Aug 1;25 (15) :2907-12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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