Melperone (hydrochloride)
Melperone hydrochloride is a butyrophenone with atypical antipsychotic properties. Melperone hydrochloride is a multireceptor antagonist with Kds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone hydrochloride has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with Kd values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone hydrochloride is also a CYP2D6 inhibitor. Melperone hydrochloride can be used for the study of schizophrenia, and agitation in the elderly[1][2][3][4].
Product Specifications
CAS Number
[1622-79-3]
UNSPSC
12352005
Hazard Statement
H225-H301-H311-H331-H370-H371
Target
5-HT Receptor; Adrenergic Receptor; Cytochrome P450; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/melperone-hydrochloride.html
Solubility
DMSO : 50 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=CC=C(F)C=C1)CCCN2CCC(C)CC2.Cl
Molecular Formula
C16H23ClFNO
Molecular Weight
299.81
Precautions
P210-P233-P240-P241-P242-P243-P260-P264-P270-P271-P280-P303+P361+P353-P362-P370+P378-P403+P233-P403+P235-P405-P501
References & Citations
[1]Lurasidone Improves Psychopathology and Cognition in Treatment-Resistant Schizophrenia
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT1 Receptor;5-HT2 Receptor; CYP2D6; D2 Receptor; α adrenergic receptor
Available Sizes
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