BNC375
Product Specifications
UNSPSC Description
BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. BNC375 exhibits good CNS-agent like properties and clinical candidate potential. [1].
Target Antigen
nAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bnc375.html
Purity
99.62
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(OC)C(NC[C@H]2C(C)(C)[C@@H]2C3=CC=C(S(N)(=O)=O)C=C3)=C1
Molecular Weight
394.92
References & Citations
[1]Andrew J Harvey, et al. Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs. ACS Med Chem Lett. 2019 Mar 25;10(5):754-760.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128575/BNC375-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128575/BNC375-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
1557240-80-8
Available Sizes
Curated Selection
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