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CBP/p300-IN-12

Product Specifications

UNSPSC Description

CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450[1].

Target Antigen

Epigenetic Reader Domain; Histone Acetyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cbp-p300-in-12.html

Purity

99.70

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

C=CC(NC1=CC=CC(NC(NC2=CC3=C([C@]4(OC(N(CC(N(CC5=CC=C(F)C=C5)[C@@H](C)C(F)(F)F)=O)C4=O)=O)CC3)C=C2)=O)=C1)=O

Molecular Weight

667.61

References & Citations

[1]Anthony Mastracchio, et al. Discovery of a Potent and Selective Covalent p300/CBP Inhibitor. ACS Med Chem Lett. 2021 Apr 5;12(5):726-731.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-132197/CBP-p300-IN-12-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-132197/CBP-p300-IN-12-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2738688-57-6

Available Sizes

Curated Selection

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