CBP/p300-IN-12
CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM) . CBP/p300-IN-12 forms a covalent adduct with C1450[1].
Product Specifications
CAS Number
[2738688-57-6]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbp-p300-in-12.html
Purity
99.72
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C=CC(NC1=CC=CC(NC(NC2=CC3=C([C@]4(OC(N(CC(N(CC5=CC=C(F)C=C5)[C@@H](C)C(F)(F)F)=O)C4=O)=O)CC3)C=C2)=O)=C1)=O
Molecular Formula
C33H29F4N5O6
Molecular Weight
667.61
References & Citations
[1]Anthony Mastracchio, et al. Discovery of a Potent and Selective Covalent p300/CBP Inhibitor. ACS Med Chem Lett. 2021 Apr 5;12 (5) :726-731.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300
Available Sizes
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