NSC-370284
NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC) . NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5[1].
Product Specifications
CAS Number
[116409-29-1]
UNSPSC
12352005
Target
STAT; TET Protein
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-370284.html
Purity
99.27
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(C(N2CCCC2)C3=CC(OC)=C(OC)C(OC)=C3)C=C(OCO4)C4=C1
Molecular Formula
C21H25NO6
Molecular Weight
387.43
References & Citations
[1]Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8 (1) :2099.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3; STAT5; TET1
Available Sizes
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