6-OAU
Product Specifications
Product Name Alternative
GTPL5846
UNSPSC Description
6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function[1][2].
Target Antigen
Antibiotic; Bacterial; ERK; GPR84
Type
Reference compound
Related Pathways
Anti-infection;GPCR/G Protein;MAPK/ERK Pathway;Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/6-OAU.html
Purity
99.91
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1NC(C=C(NCCCCCCCC)N1)=O
Molecular Weight
239.31
References & Citations
[1]Suzuki M, et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91.|[2]Reyes AWB, et al. Immune-metabolic receptor GPR84 surrogate and endogenous agonists, 6-OAU and lauric acid, alter Brucella abortus 544 infection in both in vitro and in vivo systems. Microb Pathog. 2021 Sep. 158:105079.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12764/6-OAU-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12764/6-OAU-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
83797-69-7
Available Sizes
Curated Selection
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