6-OAU

6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function[1][2].

Product Specifications

CAS Number

[83797-69-7]

Product Name Alternative

GTPL5846

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; ERK; GPR84

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/6-OAU.html

Purity

99.77

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1NC(C=C(NCCCCCCCC)N1)=O

Molecular Formula

C12H21N3O2

Molecular Weight

239.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Suzuki M, et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288 (15) :10684-91.|[2]Reyes AWB, et al. Immune-metabolic receptor GPR84 surrogate and endogenous agonists, 6-OAU and lauric acid, alter Brucella abortus 544 infection in both in vitro and in vivo systems. Microb Pathog. 2021 Sep. 158:105079.