Coumarin-3-carboxylic Acid
Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line[1][2].
Product Specifications
CAS Number
531-81-7
Product Name Alternative
2-Oxochromene-3-carboxylic acid
UNSPSC
12352005
Hazard Statement
H301
Target
Fluorescent Dye
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/coumarin-3-carboxylic-acid.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O1)C(C(O)=O)=CC2=C1C=CC=C2
Molecular Formula
C10H6O4
Molecular Weight
190.15
Precautions
H301
References & Citations
[1]Aimin Song, et al. A convenient synthesis of coumarin-3-carboxylic acids via Knoevenagel condensation of Meldrum's acid with ortho-hydroxyaryl aldehydes or ketones. Tetrahedron Letters. 2003 Feb;44 (9) : 1755-1758.|[2]Kostova I, et al. New Samarium (III), Gadolinium (III), and Dysprosium (III) Complexes of Coumarin-3-Carboxylic Acid as Antiproliferative Agents. Met Based Drugs. 2007;2007:15925.|[3]Náfrádi M, et al. Application of coumarin and coumarin-3-carboxylic acid for the determination of hydroxyl radicals during different advanced oxidation processes[J]. Radiation Physics and Chemistry, 2020, 170: 108610.|[4]Wu L, et al., Ultrasmall iron oxide nanoparticles cause significant toxicity by specifically inducing acute oxidative stress to multiple organs. Part Fibre Toxicol. 2022 Mar 29;19 (1) :24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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