Coumarin-3-carboxylic Acid

Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line[1][2].

Product Specifications

CAS Number

[531-81-7]

Product Name Alternative

2-Oxochromene-3-carboxylic acid

UNSPSC

12352005

Hazard Statement

H301

Target

Fluorescent Dye

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/coumarin-3-carboxylic-acid.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O1)C(C(O)=O)=CC2=C1C=CC=C2

Molecular Formula

C10H6O4

Molecular Weight

190.15

Precautions

H301

References & Citations

[1]Aimin Song, et al. A convenient synthesis of coumarin-3-carboxylic acids via Knoevenagel condensation of Meldrum's acid with ortho-hydroxyaryl aldehydes or ketones. Tetrahedron Letters. 2003 Feb;44 (9) : 1755-1758.|[2]Kostova I, et al. New Samarium (III), Gadolinium (III), and Dysprosium (III) Complexes of Coumarin-3-Carboxylic Acid as Antiproliferative Agents. Met Based Drugs. 2007;2007:15925.|[3]Náfrádi M, et al. Application of coumarin and coumarin-3-carboxylic acid for the determination of hydroxyl radicals during different advanced oxidation processes[J]. Radiation Physics and Chemistry, 2020, 170: 108610.|[4]Wu L, et al., Ultrasmall iron oxide nanoparticles cause significant toxicity by specifically inducing acute oxidative stress to multiple organs. Part Fibre Toxicol. 2022 Mar 29;19 (1) :24.