KHS101 hydrochloride

KHS101 hydrochloride could selectively induce a neuronal differentiation phenotype and interacts with transforming acidic coiled-coil-containing protein 3 (TACC3) .

Product Specifications

CAS Number

[1784282-12-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

FGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/KHS101_hydrochloride.html

Purity

99.65

Solubility

DMSO : 160 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H]Cl.CC(CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1)C

Molecular Formula

C18H22ClN5S

Molecular Weight

375.92

Precautions

H315, H319, H320

References & Citations

[1]Wurdak H, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci U S A. 2010 Sep 21;107 (38) :16542-7.|[2]Polson ES, et al. KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice. Sci Transl Med. 2018 Aug 15;10 (454) . pii: eaar2718.