Damnacanthol
Damnacanthol is a natural product that can be isolated from Damnacanthus major[1]. Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells[2].
Product Specifications
CAS Number
[477-83-8]
UNSPSC
12352005
Target
Lipoxygenase; NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/damnacanthol.html
Purity
99.76
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C=CC=C2)C(C3=CC(O)=C(CO)C(OC)=C13)=O
Molecular Formula
C16H12O5
Molecular Weight
284.26
References & Citations
[1]Ayyangar N R, et al. Anthraquinone and anthrone series—XXIII: The non-identity of 1: 3: 8-trihydroxy-2-hydroxymethyl-anthraquinone with versicolorin and a synthesis of damnacanthol and damnacanthal. Tetrahedron, 1959, 6 (4) : 331-337.|[2]Dzoyem JP, et al. Inhibition of Nitric Oxide Production in LPS-Stimulated RAW 264.7 Macrophages and 15-LOX Activity by Anthraquinones from Pentas schimperi. Planta Med. 2016 Sep;82 (14) :1246-51.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
15-LOX
Available Sizes
Curated Selection
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