FTX-6746

FTX-6746 is an orally active PPARG inhibitor. FTX-6746 shows potent tumor inhibition in mouse xenograft models[1].

Product Specifications

CAS Number

[2829349-96-2]

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ftx-6746.html

Purity

98.68

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

ClC(C=CC(C#N)=C1)=C1C2=CC(C3=C(F)C=C(F)C=C3N2)=O

Molecular Formula

C16H7ClF2N2O

Molecular Weight

316.69

References & Citations

[1]Mertz J, et al. Novel inhibitors of the luminal lineage transcription factor peroxisome proliferator-activated receptor gamma (PPARG) durably eradicate tumors in urothelial cancer (UC) animal models[J]. European Journal of Cancer, 2022, 174: S33-S34.