7,8-Dihydroxyflavone

7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF) . Displays therapeutic efficacy toward various neurological diseases[1].

Product Specifications

CAS Number

[38183-03-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Trk Receptor

Type

Natural Products

Related Pathways

Apoptosis; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/7,8-Dihydroxyflavone.html

Purity

99.90

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1C=C(C2=CC=CC=C2)OC3=C(O)C(O)=CC=C13

Molecular Formula

C15H10O4

Molecular Weight

254.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39 (3) :638-50.