Pamoic acid (disodium)

Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect[1].

Product Specifications

CAS Number

[6640-22-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ERK; GPR35

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pamoic-acid-disodium.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=C(C(C=CC=C2)=C2C=C1C(O[Na])=O)CC(C(C=CC=C3)=C3C=C4C(O[Na])=O)=C4O

Molecular Formula

C23H14Na2O6

Molecular Weight

432.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78 (4) :560-8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Noncoding RNA Res. 2025 May 15:13:184-196.|Clin Transl Med. 2025 Apr;15 (4) :e70311.|Curr Eye Res. 2025 Jun 24:1-9.|Int Immunopharmacol. 2024 Jul 23:139:112720.